3 Recent Articles on the Serotonin Theory of Depression 

I read a LOT of literature on neuroscience, brain research, and psychotropic medications. In the past six weeks, three important articles were released related to the serotonin theory of depression.

Article 1 

The first came out on July 20, 2022:

Moncreiff, Joanna, Ruth Cooper, Tom Stockmann, Simone Amendola, Michael Hengartner, and Mark Horowitz. “The Serotonin Theory of Depression: A Systemic Umbrella Review of the Evidence.” Molecular Psychiatry. Published online July 20, 2022.

It created quite a “buzz.” As the title suggests, it calls into question the serotonin theory of depression.

As soon as it was released, I read many biblical counselors touting this article. At least one proclaiming that all biblical counselors were owed an apology from the psychiatric world for having said biblical counselors were wrong to question the serotonin theory.

I also saw some biblical counselors using the article to then call into question the efficacy of all SSRIs (Selective Serotonin Reuptake Inhibiters) for treating any depression.

More momentarily on how we biblical counselors might use such research…

Article 2 

The second article released September 6, 2022.

Pies, Ronald and George Dawson. “Serotonin or Not, Antidepressants Work.” Psychiatric Times,


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